THOMAS Cook is to close its New Street store in Huddersfield with the loss of nine jobs as part of plans to axe 200 travel shops nationwide.
The company has now launched a 90-day consultation period with staff.
A spokeswoman said the store was chosen for closure because its lease is due to expire.
The town's second Thomas Cook outlet at High Street is unaffected and will continue to trade.
The 170-year-old group, which came close to collapse last month, racked up losses of almost £400 million after a year in which the slump in consumer confidence and the Arab Spring wrecked demand for its package holidays.
It will close 200 loss-making stores over the next two years as their leases expire - 125 more than previously announced - after completing a recent merger with the Co-op’s high street travel arm.
The company, which has 1,300 shops, confirmed that 661 staff in 115 stores are expected to be told today and tomorrow that their branch could close.
It has set out a turnaround plan for the UK business, including focusing on fewer and better quality hotels and a drive for more online bookings.
But analysts said the company faced another difficult year as the UK teetered on the edge of another recession.
Interim chief executive Sam Weihagen said: "There’s no silver bullet to turning around the UK business but I’m confident that the measures will improve the profitability in years to come.
"Thomas Cook is a very strong brand in the UK and it has enormous possibilities to make sure it becomes a profitable business."
The firm was plunged into crisis last month after it went back to its lenders to ask for an additional £100 million lifeline, sparking fears of a collapse.
