NHS fraud will be highlighted at Huddersfield Royal Infirmary this month.
Millions of pounds every year are siphoned away from patient services through corrupt contractors and individuals.
But counter-fraud measures have saved the NHS more than £478m since 1999.
The NHS Counter-Fraud and Security Management Service will be visiting the Infirmary on October 12 to talk to staff and patients about the issue.
They will be in the hospital restaurant from 10.30pm to 2pm.
Matthew Willis, press officer for the NHS Counter-Fraud Service said: "This is not a victimless crime. It takes money away from frontline services.
"It involves anything from claiming exemption from prescriptions to which they are not entitled, to staff fiddling their expenses.
"We are taking action against drug companies for price fixing involving hundreds of millions of pounds."
Counter-fraud staff will be visiting 200 hospital sites all over England and Wales during the second annual NHS Fraud Awareness Month in October.
The first awareness month was held last year.
Many staff were unaware of NHS fraud and how to report it, until it was highlighted.
Derek Johnson, operational manager of the counter-fraud service in the North and Yorkshire said: "It is not only important to tackle fraud nationally, but locally as well.
Jim Gee, chief executive of the NHS counter-fraud service, said: "Changing the perception of fraud is central to stopping it.
"By meeting people and informing them of the effect it can have on the NHS, we will create a culture where fraud will not be tolerated."
Between 1999 and 2004, counter- fraud work cut pharmaceutical patient fraud by 60%, dental patient fraud by 25%, optical patient fraud by 23% and in some areas, fraud by NHS professionals by between 31% to 46%.
People caught out defrauding the NHS can face a jail sentence and there is a 97% successful prosecution rate.