Bristol City manager Lee Johnson watched three players leave the field in the weekend 2-2 draw away at Blackburn Rovers.
And at least two will miss the clash with Huddersfield Town at Ashton Gate on Saturday, with the third a serious doubt.
Influential midfielder Korey Smith was shown a red card for a push on Grant Hanley and faces a three match ban, ruling him out of the final two games of the season and the opening game of 2016/17.
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Meanwhile, on loan defender Adam Matthews went off with a hamstring injury and will not play again this season.
And centre back Aden Flint, who has made more appearances than any other Bristol City player this term, was subbed after 45 minutes with a twisted knee and looks set to miss the game - with Alex Pearce, signed on loan from Reading in January, likely to deputise.
Town welcomed back Kyle Dempsey from injury for their 1-1 draw with Birmingham at the weekend.
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But Philip Billing missed that game with a calf problem and Jonathan Hogg remains on the sidelines recovering from a knee injury.
David Wagner believed he might be fit before the end of the season, but there is no point in taking risks ahead of the summer.