Town sit third in the table after consecutive 2-1 league wins over Brentford and Newcastle United followed by a dramatic 1-1 draw away to Aston Villa on Tuesday.
After being under the cosh for large periods of the game, substitute Michael Hefele salvaged a point with a bizarre 87th-minute equaliser - the 25-year-old German centre-back chasing down Villa keeper Pierluigi Gollini and the Italian's clearance hitting the Town player to rebound into the net.
With confidence coursing throughout the club, this weekend's fixture brings Barnsley to the John Smith's Stadium for the first time since March 2014, when Town won the Championship clash 5-0.
Head coach David Wagner will be hoping for a similar impressive scoreline in front of what is hoped will be a bumper 20,000-plus crowd for the encounter.
But he has told his players to expect a tough test.
Ahead of the clash, the Examiner looks at a few of the interesting club connections between the two clubs through the years, with a quartet of links outlined below.
4 Links between Huddersfield Town and Barnsley FC
Barnsley-born, the forward began his career with his hometown side in 1921, scoring on his debut in an FA Cup replay against Norwich before going on to make 161 appearances for the club.
Capped six times for England, Hine joined Huddersfield from Leicester City in 1932, playing for the Terriers for a season before joining Manchester United and then returning to Oakwell in 1934 to become Barnsley's top all-time goalscorer.
After falling out of favour at West Bromwich Albion, Wallwork joined Barnsley on loan in November 2006.
However the former Manchester United player only managed two appearances for the Tykes after being stabbed in a nightclub altercation later the same month.
After returning from his injuries, Wallwork joined Huddersfield Town on loan in September 2007 where he went on to score three goals in 16 appearances for the Terriers.
The full-back came through the youth ranks at Barnsley, making 66 appearances for the Tykes over a five year period at Oakwell.
Williams then joined Huddersfield in August 2007 on a three-year deal for an undisclosed fee, going on to feature for the Terriers more than 70 times before being released in the summer of 2010.
The former striker guided Barnsley to 2009/10 Championship safety after taking over the club languishing at the bottom of the table in September 2009.
After resigning from his position at the end of the 2010/11 season due to differences with the board, Robins took charge of Huddersfield Town in February 2013, saving the Terriers from League One relegation with a 2-2 draw against former side Barnsley on the final day of the 2012/13 season.