Town have played the Rams in every season since being back in the SkyBet Championship but have failed to beat them away from home in the last 20 league encounters (lost 18, drawn two).
However, after a last-gasp Elias Kachunga winner back in October, Wagner's men could do the double over Derby for the first time since the 1937-38 season.
The 1-0 victory at the John Smith's Stadium saw Steve McClaren in charge for the visitors, who has since been sacked and replaced by Gary Rowett, with Derby going on to pick up 10 points from a possible 15 in recent weeks.
Steven Downes takes a look back at the previous five Championship meetings between the two sides below.
Huddersfield Town 1-0 Derby County
A stoppage-time winner from Elias Kachunga sent the home faithful into raptures and saw one of the iconic moments of the season.
As the forward slotted home the 92nd minute goal, head coach David Wagner was seen charging down the touchline to celebrate with his players.
Huddersfield Town 1-2 Derby County
Derby County 2-0 Huddersfield Town
In the reverse fixture, it was once again the Rams who came out on top, with Chris Martin (31) and Johnny Russell (73) on the scoresheet for the hosts.
Derby County 3-2 Huddersfield Town
Huddersfield Town 4-4 Derby County
There were plenty of goals between the two sides during this season with an incredible 13 in the two league encounters.
The game at Pride Park saw Derby's Jordon Ibe (7), Johnny Russell (45 +1:00) and Simon Dawkins (77) find the net with Harry Bunn on target in the 22nd minute for Town.
Mark Hudson made it a nervy end to the game by pulling another back in stoppage-time but Town couldn't find an equaliser before full-time.
Both sides also played out a terrific 4-4 draw at the John Smiths Stadium in the corresponding fixture.
As Gobern bagged himself a rare goal, Reece James scored direct from a corner, which is a rarity in itself.
Derby's goals game from Tom Ince (16 and 79 minutes) along with Simon Dawkins (52) and Jesse Lingard (61).