Can Huddersfield Town claim their first top six scalp of the season at the final attempt?
Here's three key battles to determine whether they can claim the points or be left ruing missed chances again...
James Husband v Ahmed Elmohamady
Both sides are likely to feature fresh faces in the full-back role, with a combination of loan regulations and suspension forcing the hands of David Wagner and Steve Bruce.
While Wagner can now restore James Husband to the line-up after missing him against parent club Middlesbrough in midweek, Bruce will have to replace the suspended Moses Odubajo - sent off at the iPro Stadium.
Ahmed Elmohamady is in line for a Tigers recall at right back, and with five assists to his name in the league this term, Husband will have to keep a careful watch on his opposite number.
The Egyptian can also play on the right hand side of midfield, and his attacking instincts have also yielded three league goals.
Husband will need to be on top form defensively, but could take advantage if Elmohamady neglects his own duties at the back in favour of attacking glory.
Nahki Wells v Michael Dawson
Sixteen goals in a side still not mathematically guaranteed their Championship place next term is fantastic return from Nahki Wells, who relishes being the main man and central forward for Wagner.
Charged with getting the majority of the goals, he has risen to the challenge with gusto.
It's no coincidence that he has no goals in his last two games, and therefore Town as a whole have hit blanks for successive fixtures.
Before that he was on the scoresheet against Leeds, turning in a fantastic display that had Wagner purring that his Bermudian frontman would be talking about that game at Elland Road long after he finally hangs up his boots.
He'll need to be back to that form if Town are to profit against Hull, and his task won't be easy against skipper Michael Dawson - who spent nine years at Tottenham Hotspur and has played the majority of his senior football in the Premier League.
But he is just one shy of Hull striker Abel Hernandez's goal tally - a man third in the list of the Championship's highest scorers.
Jamie Paterson v David Meyler
There have been calls for Steve Bruce to re-introduce some steel in to the Hull midfield following Derby's demolition job in midweek.
Step forward David Meyler, who formed one half of a brilliantly successful partnership with Jake Livermore earlier this term to create a formidable engine room.
He'll be tasked with winning control of the central areas - and stopping the guile of Jamie Paterson.
The Forest loanee was badly missed against Sheffield Wednesday and was introduced from the bench at half time.
With him pulling the strings in the middle, it gives Town an extra attacking danger rather than over-relying on the wide men.
Can his skill triumph over Meyler's steel?