According to Press Association Sport research, the club's youth set-up made the single biggest contribution to top-flight football last term than any other club.
Their graduates racked up more than twice as many top-flight minutes played as the next best academy (a total of 44,055 ) with Tottenham Hotspur second, racking up a total of 21,668.
The Red Devils' reputation for developing home-grown talent extends back to the 'Busby Babes' of the 1950s and continued through the 'Class of 92' group which played a part in the United side that dominated domestic football in the 1990s, culminating in winning the treble back in 1999.
The study, using publicly available data from soccerway.com, shows the United academy is still the number one producer of top-flight talent in England.
In their own line-up, France midfielder Paul Pogba - who rejoined United last summer in an £89 million deal - racked up 2,609 minutes while England internationals Marcus Rashford and Jesse Lingard played 1,702 and 1,367 minutes respectively.
Other non-United players to make significant contributions to the Red Devils academy total included Burnley duo Michael Keane (who has since joined Everton) and Tom Heaton, who each played 3,150 minutes.
AFC Bournemouth striker Joshua King played 2,721 minutes, while Leicester City pair Danny Simpson (2,990) and Danny Drinkwater (2,466) were also key to the high total for United.
Stoke City defender Ryan Shawcross played 3,150 minutes while relegated Sunderland used five United academy products during the season - John O'Shea, Donald Love, Paddy McNair, Darron Gibson and Adnan Januzaj.
The biggest contributor to Tottenham's total who still plays for the club was Harry Kane, with 2,536 minutes played in a season disrupted by injury.
Spurs graduates Charlie Daniels and Adam Smith each played over 3,000 minutes for Bournemouth, and Andros Townsend played 2,528 minutes for Crystal Palace.
Manchester City graduates managed 16,226 minutes to place the club third, but almost all of those were played by players who have moved on from the Etihad Stadium.
Kelechi Iheanacho (526 minutes) was the only City youth product to feature in their first team in the Premier League under Pep Guardiola all season.
City graduate Ben Mee at Burnley played 3,016 minutes while Leicester goalkeeper Kasper Schmeichel featured for 2,667 minutes.
Of last season's European qualifiers from the Premier League, Liverpool are the only one not to feature in the top 10, ranking 17th in the study with 8,753 minutes.
Surprisingly, League One champions Sheffield United made an appearance in the top 10, finishing eighth on 13,564 minutes - one place and 119 minutes ahead of Chelsea.
Full-backs Kyle Walker (2,704 minutes) and Kyle Naughton (2,718) featured extensively for Tottenham and Swansea City respectively, with Harry Maguire playing 2,306 minutes for Hull City and fellow centre-back Phil Jagielka 2,250 for Everton.
The only club from outside England to feature in the top 10 were Dutch side Ajax Amsterdam, who were 10th.
Graduates from Barcelona's La Masia finishing school made the 12th-biggest contribution, while the largest representation from outside Europe came from the youth set-up at Argentinian giants River Plate.
At the other end of the scale, relegated Hull produced the fewest minutes of any Premier League team - just 501, shared between their own players Josh Tymon (325) and Jarrod Bowen (176).
The Tigers were the only club not to have a graduate feature for any other top-flight team and their youth products also lagged over 1,000 total minutes behind those of Watford, the second-lowest ranked Premier League club in the study with 1,513 minutes.
Almost exactly half of the Hornets' total came from Manchester United winger Ashley Young (757 minutes), with the rest from their own players led by Adrian Mariappa (561).
Ahead of the 2017/18 Premier League campaign, only Philip Billing from the club's Academy is a regular Huddersfield Town first-team player although the club have previously developed the likes of Andy Booth, Jon Stead, Alex Smithies and Jack Hunt and others.
Top 20 minutes played in the 2016-17 Premier League season by graduates of each club's academy:
1. Manchester United = 44,055
2. Tottenham = 21,668
3. Manchester City = 16,226
4. Southampton = 14,340
5. West Ham = 13,907
6. Everton = 13,855
7 . Arsenal = 13,599
8. Sheffield United = 13,564
9. Chelsea = 13,445
10. Ajax = 12,617
11. Feyenoord = 12,589
12. Barcelona = 10,858
13. Crystal Palace =10,851
14. Aston Villa = 10,686
15. Middlesbrough = 10,487
16. Genk = 9,263
17. Liverpool = 8,753
18. Sporting Lisbon = 8,499
19. Derby = 7,240
20. Schalke = 7,090