Schofield put the Terriers into a 1-0 lead as early as the 4th minute when Leon Knight's perceptive through ball saw the Town midfielder clean through.
The Terriers were much the superior side on the night, with confident passing complimented by the rare sight of full backs Steve Jenkins and Gareth Evans making overlapping forays upfield to add themselves to the attack.
It wasn't long before Town went into a richly deserved 2--0 lead on 25 minutes when Kenny Irons' corner sparked off a melee which ended with Leon Knight's effort falling to Danny Schofield who hit his second of the night at the second time of asking.
The Terriers were flying in the first half but Colchester kept a tight rein on Leon Knight, with some tackles coming in too fast on the skilfull attacker.
Their game was more effective in the second half as they took advantage of the Terriers' deeper defending and invitations to attack with both hands.
Chris Hay put in a couple of enticing crosses during the second half while Andy Booth had his chances to create a winner - notably from Schofield who spurned the chance of a hat-trick later in the second half.
The crowd could sense that the Terriers had lost their first half momentum somewhat and the U's finally took a chance when, with Andy Booth off the pitch, they capitalised on a corner late in the game to afford Alan White the chance for the equaliser which he duly took.
The last few minutes saw the Terriers enduring chances from Kemal Izzett and Adrian Coote along with a fine late Thomas Pinault effort which drew a save out of Martyn Margetson.
The final whistle saw the few who had attended in the stadium breathe a collective sigh of relief.
Read Mel Booth's match report in the Examiner on Wednesday. Have your say in the messageboard below - some comments may be published in the Examiner.
Town (4-4-2): Margetson, Jenkins, Gray, Clarke, Evans, Hay (Armstrong 86), Schofield, Irons, Holland, Knight, Booth (Wijnhard 78)
Subs not used: P. Senior, Moses, Macari
Scorer: Schofield 4, 25
Colchester (4-4-2): Brown, Duguid, White, Fitzgerald, Halls, Keith, Pinault, Stockwell (Morgan 60), Izzett, McGleish (Coote 72), Barrett
Subs not used: Williamson, Johnson, Rapley
Scorer: White 82
Referee: Mr Cooper
Attendance: 7,179 (149 Away fans)
Match points follow on subsequent pages
FULL TIME - The crowd breathed a collective sigh of relief after the Terriers held on for victory.
93 mins: Izzett and Coote had chances to level the scores.
92 mins: Pinault's left footed shot was well saved. Edginess had the crowd on their feet as Town yet again offered Colchester the chance of another equaliser.
91 mins: Knight was offside.
91 mins: Leon Knight hit the ball wide after Clyde Wijnhard had put him clean through.
90 mins: Town had to survive 3 minutes of added time and Craig Armstrong was on for Chris Hay.
82 mins: The U's had a corner and Alan White lofted the ball into the back of the net past Margetson to give the match another 'entertaining' finale. It was a poor goal.
80 mins: Knight was shoved off the ball but Town couldn't use the set piece to their advantage.
78 mins: Alan White cut in and found Pinault as the U's sensed the chance of a goal from the Terriers' dour defensiveness. Clyde Wijnhard took his tracksuit off and prepared to come on as the crowd bayed for a change. The Dutchman replaced Andy Booth.
76 mins: Margetson beat away a shot from Kemal Izzett after an interception from Nathan Clarke had prevented Coote from having a shot on goal. The Terriers were defending deep again.
75 mins: The game was starting to get quiet.
70 mins: Booth crossed to the far post but there was nobody there! Schofield picked up on the ball and attacked but couldn't get a shot in.
70 mins: Booth was beaten in the air by Halls as they seemed to tire.
69 mins: Morgan crossed but Margetson easily caught the ball.
69 mins: Andy Booth was offside as Town lost their way somewhat in the middle of the second half.
68 mins: Jenkins attacked but lost control of the ball.
66 mins: Morgan was well tackled by Clarke.
65 mins: Hay came inside with the ball but his tight pass for Schofield was poor as Evans screamed for the easier ball to him.
63 mins: Gareth Evans went upfield on the attack and overlapped quickly but his cross was poor. The Terriers were being very adventurous.
62 mins: Colchester replaced Micky Stockwell with Dean Morgan.
61 mins: Jenkins worked hard to get into a crossing position. Irons passed to him and the Welshman tried to wrap his foot around the ball to cross for Chris Hay but it flew out off the top of his boot.
60 mins: Colchester eventually cleared but Town countered and Hay broke free and crossed but it was cut out by Keith.
59 mins: Chris Hay's cross was created well and dropped enticingly to be put out for a corner.
58 mins: Stockwell blocked Knight's cross.
57 mins: Town were starting to defend deep.
55 mins: Knight was felled by a challenge but the referee didn't deem it a foul.
52 mins: The Terriers were comfortably passing the ball around.
51 mins: Knight was adjudged offside after a ball over the top from Evans.
50 mins: Colchester had a brighter start to the second half but the Terriers kept them under control for the opening exchanges.
Town were definately top dog at the McAlpine as they celebrated the takeover with an easy 2-0 lead courtesy of two goals from Danny Schofield.
Their visitors were definately off the pace with only Micky Stockwell's testers posing Martyn Margetson any difficulty.
48 mins: Irons skied a lay off from Andy Booth.
47 mins: Alan White's dangerous high tackle on Leon Knight drew whistles of derision from the home crowd.
47 mins: Knight's inventive trick and pass for Danny Schofield was well meant but too long.
46 mins: Halls bullied Knight away from the ball as the game went into added time.
45 mins: Town were comfortable as the half drew to a close.
43 mins: Knight's skill led to a lay-off but Colchester intercepted.
42 mins: Hay's cross for Knight looked to be a winner until it was intercepted.
42 mins: Halls took the ball away from Knight.
38 mins: Leon Knight was floored by another off-the-ball challenge - he was definately being targetted the the opposition.
35 mins: Karl Duguid struck a free kick over the bar.
33 mins: Jenkins dealt with an awkward bouncing ball as the Terriers worked very hard to close down their visitors at every opportunity.
31 mins: Mick Stockwell's shot was saved by Martyn Margetson - he was definately the U's dangerman and Town couldn't afford to slip.
29 mins: A short free kick was hit against the Colchester wall but Town continued to attack with Evans crossing for Andy Booth to flick up but he lost control of the ball and Brown gathered gratefully.
27 mins: Town were supremely confident after Holland worked hard and broke free for Leon Knight to support Danny Schofield on a thrilling run but the chance went away from Schofield with Jenkins waiting on the other flank.
26 mins: Steve Jenkins required treatment.
25 mins: Danny Schofield tapped in easily on his second attempt in a melee from Irons' corner after Leon Knight knocked the ball down for him.
25 mins: Brown for forced into an unneccessary save to force a corner after a cheeky effort from Schofield.
23 mins: Knight was in space as he tried to beat a defender to the ball but fell over.
21 mins: Margetson came out of his goal to beat McGleish to a long ball and rolled the ball to Steve Jenkins - a move which drew ironic cheers from the Town crowd who were too used to the Welsh goalie kicking it long.
20 mins: Knight's 30 yard speculator was well timed but too easy for Brown.
19 mins: Mick Stockwell gave Town something to think about when he exploited bags of space down the right and got a shot in which whistled over Margetson's goal.
17 mins: A good Town move saw the visitors pressed all the way back to their own 'keeper.
15 mins: Jenkins linked with Hay who went past one man but was tackled by Pinault before he could line up a cross.
12 mins: Colchester won a free kick after Scott McGleish was bundled over. Joe Keith's chance was headed away by Andy Booth after it had struck the wall.
10 mins: Steve Jenkins went on a rare foray upfield and invited Chris Holland to pass to him.
9 mins: Knight couldn't control the ball after knockdown from Andy Booth went slightly wayward with Colchester defenders backing off.
8 mins: Schofield worked hard to cover with Gareth Evans.
6 mins: Leon Knight was outcrowded by John Halls after he rescued Gareth Evans' slightly wayward pass.
5 mins: Andy Booth couldn't reach a cross as Town continued to press.
4 mins: Danny Schofield calmly slotted home to put the Terriers into the lead after a great through ball by a perceptive Leon Knight from the edge of the box.
3 mins: The U's were in an attacking frame of mind with plenty of people committing to attack.
2 mins: A relatively unpopulated McAlpine watched a slow start to the game.
Thomas Heary was unable to play because of an ankle injury but Chris Holland had recovered enough from illness to retain his place in the starting lineup. Heary's place on the bench was taken up by Paul Macari.
Kemal Izzett, Muzzy Izzett's brother, started the match for Colchester in midfield with John Halls on loan from Arsenal in defence.