Protesters will gather in St George's Square before the march through the town centre, and will return to the square to hear the guest speakers.
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Here are the speakers lined up for Saturday's rally:
Jason McCartney
Jason McCartney during debate in Parliament on future of Huddersfield's A&E
The Colne Valley MP will be the key speaker at the event. The Conservative member has been one of the campaign's most prominent figures arranging a debate in Parliament.
Paula Sherriff
Dewsbury MP Paula Sherriff speaking in the House of Commons
The Dewsbury Labour MP is also expected to speak at the event.
Clr David Sheard
Clr David Sheard.
The Labour Kirklees Council leader will be addressing the crowd, although not in his capacity as council leader.
Paul Cooney
Save Huddersfield Royal Infirmary A&E department meeting at Methodist Mission, Lord Street. Paul Cooney starts the addresses.
Trade unionist and former hospital trust employee Mr Cooney heads Huddersfield Keep Our NHS Public.
Jackie Grunsell
Jackie Grunsell
The Newsome GP served as a Kirklees councillor between 2006 and 2010 representing the now defunct Save Huddersfield NHS party.
Natalie Ratcliffe
Save Huddersfield Royal Infirmary A&E department meeting at Methodist Mission, Lord Street. Taking the meeting left to right, Natalie Ratcliffe, Karl Deitch, Rebecca Cobb, Elliott Hinchliffe.
Natalie is a representative for Unison in Yorkshire and a founder of the #HandsOffHRI campaigner.
Karl Deitch
Junior doctors strike Feb 10, 2016: Huddersfield Royal Infimary with #HandsOffHRI organiser Karl Deitch (right) and BMA rep Pooja Bijour (2nd right) (Image: Mark Hemingway)
Karl is the chair of #HandsOffHRI
Lianne Hunter
Lianne Hunter of Huddersfield University SU addresses the crowd
Lianne is a Huddersfield National Union of Students (NUS) leader.
