One person was killed and several injured in a crash above Holmfirth.
Emergency services launched a huge rescue operation on Sunday afternoon.
Two cars, a VW Polo and an Audi A3, and a camper van had collided on Greenfield Road, which runs from Holmfirth across the moors to Greenfield.
The Yorkshire Air Ambulance and the North-West Air Ambulance flew to the scene shortly after 4.45pm and took two injured people to hospital.
Fire crews from Slaithwaite, Huddersfield and Cleckheaton were called and freed the driver of the camper van, who was trapped by his legs.
A man in the Polo, which left the road, died and two others in the car were hurt.
The car was in a drainage ditch at the side of the road and was badly damaged.
The driver of the Audi was also badly injured, while the passenger in the camper van was slightly hurt.
Watch Commander Matthew Green, of Slaithwaite, said: “It happened on the undulating stretch about half a mile past Wessenden Head.
"When we arrived there were a man still in the Audi and a man in the driving seat of the camper van, but everybody was out of the Polo.
“We used spreading gear to free the trapped driver in the camper van, who was trapped by his legs.
"One of the passengers in the Polo had been badly injured. Members of the public and a police officer were trying to help him but he has died.”
The road was likely to remain closed for hours and traffic heading from Holmfirth was diverted off up Wessenden Head Road.
The road in the opposite direction was closed in Greenfield. Police launched a major incident inquiry and appealed for witnesses.
A police spokesman confirmed there had been a fatality.