UP to 500 hospital workers will start a five-day strike this weekend.
Unison members at the Mid-Yorkshire Health Foundation Trust, which includes Dewsbury District Hospital, have already staged walkouts over plans to impose pay cuts of up to £2,800 on around 300 staff.
They have now voted for industrial action against what they say is the threat of 70 compulsory redundancies.
Unison’s Mid Yorkshire Health branch regional organiser, Jim Bell, said: “The members are determined to do what's necessary.”
Mid-Yorkshire Health Trust’s HR director, Graham Briggs, claimed there was no threat of compulsory redundancies.
He added: “We will make every effort to ensure services to patients are not affected.
“In particular we are asking the unions to ensure that patients who have been referred for cancer tests or are having cancer treatment do not have their care disrupted and that a minimum level of staff in that department do not take strike action.”
The strike will start at midnight on Sunday and go through to midnight on the following Friday.