David Wagner will be looking for his side to build on the 1-1 draw at home to Birmingham City in their previous outing while also hoping for a better away showing from their last trip away to Fulham FC.
And it promises to be an intriguing encounter with the Bluebirds managed by former Town boss Neil Warnock, replacing Paul Trollope at the start of October.
LAST TIME OUT: Cardiff City 2 Huddersfield Town 0, 12.09.15
The 67-year-old has already gone about stamping his authority on the South Wales side, bringing in a number of free agents with performances also showing encouraging signs despite results not yet matching the improvement.
Ahead of the clash, the Examiner looks at a few of the other interesting club connections between the two clubs through the years, with the top 4 club links outlined below.
The striker scored 11 times in 34 Town games between October 1966 and February 1968 and had two spells at Cardiff, memorably netting in a European tie against Real Madrid in 1971.
Born in Cardiff and managed his home-city club in the mid Nineties, the former Leeds United and Wales midfielder was assistant to Peter Jackson in his two spells as Town manager.
The striker proved popular with fans wherever he played, and the former Republic of Ireland frontman’s nomadic career included stop-offs at both Cardiff and Town.