A victory over PNE, managed by former Town boss Simon Grayson, would see Town a step closer to guaranteeing a play-off place at the end of the season.
However, Preston harbour their own slim ambitions of a top six finish – currently eight points behind Sheffield Wednesday with five games to go.
Early team news for Town suggests Sean Scannell and Harry Bunn could be close to a return to the matchday squad but on-loan Chelsea FC duo Kasey Palmer and Izzy Brown remain sidelined along with long-term absentee Jon Gorenc Stankovic.
So who would pick for Friday's afternoon's game if you were David Wagner? Use our team selector below to name your starting XI for the weekend clash.