TOWN suffered a fourth defeat in six Championship matches as Hull notched early and late goals at the KC Stadium.
Robert Koren netted in the eighth minute, shooting home from Stephen Quinn's low shot, and on-loan Sunderland midfielder David Meyler made sure of the points in the fourth minute of time added on when he drove in Jay Simpson's centre.
Meyler had hit the bar two minutes earlier.
Town, who brought Jermaine Beckford off the bench for the closing stages, had plenty of possession, but struggled to create any real chances.
Hull's former Town loan centre-back Alex Bruce was shown a straight red card after the final whistle by referee Howard Webb after pushing Alan Lee.
Hull accused Lee of catching Bruce with an elbow.