The visitors head into the game unbeaten in the league and on the back of an impressive mid-week Champions League away victory at Benfica.
That's in stark contrast to David Wagner's side, who are looking for a first win in eight games in all competitions.
The German head coach will be hoping to spring a surprise to kick-start their season against a United side depleted by a number of injuries.
Here you can find all the build up, live action and reaction from the John Smith's Stadium.
Mourinho disappointed with his players’ attitudes.
Town 2-1 United
90+4: Unbelievable block by Zanka to keep it 2-1.
90+4: United throw.
90+3: Williams called offside.
Ince off for Malone.
90+2: Schindler with two mammoth blocks to keep out United through balls.
90+1: Van La Parra earns a corner for Town.
Four minutes added - met with groans from the Town fans.
90: Town free kick on the right.
90: The keeper has control of it and he’s slowing the tempo right down.
89: Desperately close to a goal as Van La Parra gets to the ball before De Gea, but two United defenders snuff out the danger.
88: United free kick in their own half.
87: The ball is too long for any United men.
87: It’s defence versus attack.
Town hook the ball clear, United pick it up and it’s another wave of pressure.
86: Lossl fumbles Lingard’s cross, but the ref says he’s been fouled by Lukaku.
Let off for Town.
85: Van La Parra wastes some valuable time, but he can’t win the throw in the United half.
Back come the Red Devils...
85: Anywhere will do for Town now.
84: It’s all United now.
The visitors earn another corner from the right.
83: Fiercely driven cross is put into the box by Rashford, but Lossl holds on.
82: Young’s cross is inches too high for Lukaku.
81: The Town faithful are doing their best to drag the Terriers over the line here...
80: Great ball from Mooy, but it just slips out of play before Van La Parra can get there.
79: Williams goes in the book for disagreeing with the ref.
United free kick on half way.
78: Great cross by Lukaku and Rashford rises to convert at the back post.
76: Great save by Lossl to keep out a headed effort by Herrera.
75: Lingard flies up the left, but Smith is there to shut the door with a slide tackle.
74: Valencia strays offside.
74: Mounie flicks on the free kick, but it’s straight to De Gea who launches another United attack.
73: The skipper wins a free kick after being bundled over by Rashford on the byline.