The German will be hoping to arrest a slump which has seen Town fail to claim victory in their last seven outings in all competitions.
In comparison, Jose Mourinho's side remain unbeaten in the Premier League so far this campaign and come into the encounter on the back of a 1-0 away win over Benfica in the Champions League.
During today's press conference Wagner is expected to give an injury update on a host of his stars – including the latest on Michael Hefele (achilles), Kasey Palmer (hamstring), Collin Quaner (calf) and Steve Mounié (heel).
The Examiner's Blake Welton will be on hand to report live from the pre-match press conference with Raj Bains back in the office providing all the up-to-date news via the LIVE Blog below.
That's all from the press conference
Lots to take away from that: Mounie fit, Billing may need surgery, Town won’t change formation, Palmer on his way back, Quaner ready for Liverpool and Manchester United WILL have Marcus Rashford available.
We’ll have a full transcript of the Wagner press conference incoming, and plenty of build up for tomorrow’s game as well - all on Examiner.co.uk
Mourinho confirms Rashford is fit
Manchester United have players missing, but Marcus Rashford won’t be one of them
Huddersfield must show improvement from Tottenham loss
That steep loss to Spurs has clearly been on the minds at Town, with both manager and player mentioning their desire to show they’ve learnt lessons from that defeat
Mooy looking forward to testing himself
Strong words from the usually quiet Mooy, who seems up for this one
Mooy getting used to travelling for Australia
Even suggests it’s ‘not as bad as last year’ - see if that’s the same after the 24 hour trip to Honduras!
'Anything can happen'
Aaron Mooy not shying away from suggesting an upset
Every game is massive
Mooy reflects what his manager said earlier, admitting Man Utd is a special fixture, but no more important than any other game
Mooy: Still early doors
The star man admits Town are still trying to prove they belong at this level
That's all from David Wagner, latest from Aaron Mooy coming up...
Town’s number 10 is in the seat and ready to go
Wagner on Scott Malone's first Premier League start
Reading between the lines: Lowe back for tomorrow’s game?
No issues with leadership for Town
There’s enough ‘leaders in the group’
Wagner praising the 'HTAFC family'
Togetherness the key, according to the German
No knee jerk system changes for 'adaptable' Wagner
The boss clearly isn’t of the opinion that now is the time to start muddling with the system that saw Town promoted
Town still adapting to Premier League
Wagner admits this level is a ‘learning curve’ for his squad
Town will REMAIN in a lone striker system this weekend
Only one forward will start this weekend, but there is a chance of seeing them both playing further down the line
Manchester United? Just another game...
Town boss is refusing to be drawn on any extra significance of tomorrow’s opponents
Wagner not worried by lack of goals
Boss admits struggling for goals is a problem, but there is work being done to solve it
GOOD NEWS: Kasey Palmer on the verge of return
There’s a spot waiting for him in the hole just behind the striker...
Wagner clear on positive intentions
The boss doesn’t sound like a man who’s planning on parking the bus tomorrow afternoon...
Billing update: possible TWELVE WEEK absence
Shame for young Billing after such a positive start to life in the Premier League - good to have Quaner coming back, though. Has been bright from the bench.
Swansea result in the past
Wagner says they’ll learnt what they needed to from that Swansea game, and focus is fully on Manchester United now, and not the past
Big boost: Steve Mounie is BACK
Town’s record signing will be ready for Manchester United this Saturday
Who needs Ozil when you’ve got Mooy?
Wagner to Leicester?
Let’s be honest, he’s already turned down bigger jobs...
Huddersfield aiming to take points
You can’t ever fault the ambition of HTAFC under David Wagner
DW: Progress made since Tottenham loss
The head coach is insistent his side have learnt from that heavy loss to Spurs
Great footage of the last time Man Utd were in Huddersfield
Following on from that earlier stat, here’s the footage to match!
Excited, but not overawed
Wagner measured as usual ahead, despite the size of the opponent
Biggest club in the world?
David thinks Man Utd might be