The German forward was the quickest to react after Aaron Mooy’s penalty was saved by PNE goalkeeper Chris Maxwell in the sixth minute of stoppage time.
In an opening 45 minutes in which David Wagner's side dominated, the visitors took a surprise lead through Aiden McGeady's superb strike before Elias Kachunga headed level for the hosts just before the interval.
The home side then took the lead in the second-half through Jack Payne’s diving header before Jordan Hugill made it 2-2.
And as the game looked to be heading for a point apiece, Town were awarded a penalty after Kachunga was fouled in the penalty box with Quaner tucking home the rebound from Mooy's thwarted attempt.
But who was Huddersfield Town's Man of the Match? Have a look below at Steven Downes’ assessment and have your say with our gadget as well.
Made some good saves when called up but was a bit rash with his decision-making in his area at times - 7 (out of 10)
Not in the game as much as normal but his effort and energy can never be questioned - 7
Was busy as ever making himself available with his overlapping runs down the wings - 7
The German defender was solid at the back as ever and marshaled the defence well - 7
The fans favourite's passing was slightly off but nonetheless made some important clearances when necessary - 7
Unlucky to see his penalty saved but was a controlling influence throughout and assisted in Town’s first goal -7
Was at his usual combative self in the middle of the pitch but also impressed moving the ball forward and creating attacks as well - 8
Scored Town’s first goal and was a constant menace for the Preston North End defence -8 (MOTM)
Unable to make a real impact after being forced off through injury just after the half-hour mark - 6
Rajiv van La Parra
Another frustrating day at the office where nothing came off for the Dutch winger despite his best efforts - 6
Constantly lively upfront and also looked to get on the ball and cause problems for PNE at every opportunity - 8
Jack Payne (for Phillip Billing, 36) - Excellent on his introduction and scored a superb diving header - 8
Collin Quaner (for Nahki Wells, 86) - Showed a poacher's instinct to grab the all-important winner and how crucial it could be - 8
Mark Hudson (for Jack Payne, 90+8) - Didn’t have time to make an impact - 5