Three points for the Terriers could see them leapfrog a number of their relegation rivals with FA Cup action meaning a reduced schedule of league fixtures at the weekend.
Even more importantly, a victory would see them move seven points clear of the Eagles who currently occupy the final relegation place of 18th.
One game that has to go Town's way this weekend is West Bromwich Albion's trip to Dean Court to take on AFC Bournemouth.
The Cherries are thirteen points ahead of their opposition, but with the Baggies desperate to get a result in their attempt for survival, it could make for a thrilling game.
The Potters have yet to gather any momentum after Paul Lambert took the reigns from Mark Hughes in mid-January.
In comparison, after a shaky start to the season, Everton have managed to turn things around under the guidance of Sam Allardyce and currently sit in the top half of the table and three points off the mythical 40 point mark.
The final league game looks to be a goal fest with Watford travelling to Anfield for the late kick-off against Liverpool - when these two sides met earlier in the season it made for a sensational clash, ending 3-3.
Swansea, revitalized under new manager Carlos Carvalhal, host Tottenham Hotspur with Mauricio Pochettino's men desperate for a trophy and a reaction after their shock Champions League exit in mid-week.
Like Spurs, United will be hoping for better fortune after disappointingly being knocked out of the Champions League by Sevilla on Tuesday evening.
With the international break after this weekend, Huddersfield could be six points ahead of the Saints with a win over the Eagles on Saturday.