The 24-year-old, already fighting for the Commonwealth belt in Leeds on October 4, will go for the national strap in Liverpool on November 29.
Nurse fancies a tilt at reigning champion Willie Limond as part of the Nathan Cleverly versus Tony Bellew showdown at the Echo Arena.
But the Scot could step up to European level, leaving Nurse to take on either Welshman Chris Jenkins or Scouser Thomas Stalker, who meet in an eliminator in Liverpool on September 25.
Nurse’s British title fight, which could incorporate the Commonwealth crown if he is successful next month, was due to take place on the proposed Kell Brook bill on December 6.
But that show has been postponed after Brook was stabbed while on holiday in Tenerife.
“The main thing is a date has been set and we know when we will be fighting for the British title,” said trainer Chris Aston, who was in the corner as Huddersfield cruiserweight Mark Hobson won a Lonsdale belt outright in the nineties.
“Obviously at this stage, we’re still waiting to see who the eventual opponent will be.
“We’d like to be up against Willie Limond, because he is a great fighter and it would be an attractive bout.
“But Tyrone is ready to face any opponent, and it’s not something we have control over.
“What will be, will be, and we will enjoy waiting to see what develops.”
Nurse is also waiting to discover his Commonwealth title opponent.
An African or Australian looks most likely.
The fight will form a key part of the bill when unbeaten Leeds star Josh Warrington faces Italian Davide Dieli for the vacant European featherweight championship.
The show will also feature Liverpudlian super-middleweight Callum Smith, who along with Nurse and Warrington, is among three of the six nominees for the British board’s Young Boxer of the Year award.
“It’s a top bill,” added Aston. “Having Josh and Callum on there adds that bit of incentive for Tyrone to put on a show.
“It’s great that we have two televised title fights coming up and this is a chance for Tyrone to showcase his talents.
“I believe he is destined for big things, and now he can underline that.”
Nurse, who has held both the Central area and English light-welter titles, is seeking a 30th career win in his 31st fight.
He has been sparring with Denton Vassell.
The Mancunian has a British welterweight title eliminator against Stourbridge’s Sam Eggington this Saturday.
For tickets for the Nurse show, ring Aston on 07917 881114.