EDDIE Morra (Bradley Cooper) has been wrestling with writer’s block for weeks and now his girlfriend Lindy (Abbie Cornish) has finally given up on him.

At his lowest ebb, Eddie meets his former brother-in-law, Vernon (Johnny Whitworth), who furnishes the struggling writer with a wonder pill called NZT, which reportedly increased brain activity and unleashes untapped creativity.

Eddie swallows the clear pill and the next morning, he discovers he has furiously churned out the first 40 pages of his magnum opus.

As Eddie becomes addicted to the medication, he metamorphoses from hopeless bum into a suave, ultra-confident and charming man about town, winning back Lindy and earning the respect of powerful Wall Street mogul, Carl Van Loon (Robert De Niro). However, Eddie’s supply of pills is finite and in order to continue his meteoric rise, he must acquire a new stash.